Formal total synthesis of (-)-balanol: a potent PKC inhibitor
Formal total synthesis of (-)-balanol: a potent PKC inhibitor
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Date
2010-01-20
Authors
Yaragorla, Srinivasarao
Muthyala, Ramaiah
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Abstract
An efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from the commercially available pentane1,5-diol. A Shi epoxidation and Pd(0)-mediated nitrogen substitution with double inversion established the correct configuration of the balanol precursor 3. © 2009 Elsevier Ltd. All rights reserved.
Description
Keywords
Balanol,
Pd(PPh ) -mediated epoxide opening 3 4,
PKC inhibitors,
Shi epoxidation,
Triphenyl phosphine mediated rearrangement
Citation
Tetrahedron Letters. v.51(3)