Formal total synthesis of (-)-balanol: a potent PKC inhibitor
Formal total synthesis of (-)-balanol: a potent PKC inhibitor
| dc.contributor.author | Yaragorla, Srinivasarao | |
| dc.contributor.author | Muthyala, Ramaiah | |
| dc.date.accessioned | 2022-03-27T08:50:21Z | |
| dc.date.available | 2022-03-27T08:50:21Z | |
| dc.date.issued | 2010-01-20 | |
| dc.description.abstract | An efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from the commercially available pentane1,5-diol. A Shi epoxidation and Pd(0)-mediated nitrogen substitution with double inversion established the correct configuration of the balanol precursor 3. © 2009 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | Tetrahedron Letters. v.51(3) | |
| dc.identifier.issn | 00404039 | |
| dc.identifier.uri | 10.1016/j.tetlet.2009.10.120 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0040403909020814 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/11909 | |
| dc.subject | Balanol | |
| dc.subject | Pd(PPh ) -mediated epoxide opening 3 4 | |
| dc.subject | PKC inhibitors | |
| dc.subject | Shi epoxidation | |
| dc.subject | Triphenyl phosphine mediated rearrangement | |
| dc.title | Formal total synthesis of (-)-balanol: a potent PKC inhibitor | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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