Synthesis of 3,8,13,18-tetrachloro-2,7,12,17-tetramethoxyporphyrin
Synthesis of 3,8,13,18-tetrachloro-2,7,12,17-tetramethoxyporphyrin
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Date
2011-05-25
Authors
Rana, Anup
Panda, Pradeepta K.
Journal Title
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Abstract
Vilsmeier-Haack formylation of 3,4-dimethoxypyrrole led to the unprecedented formation of 3-chloro-4-methoxypyrrole-2-aldehyde instead of the desired dialdehyde. Subsequent reduction and acid catalyzed cyclization led to the formation of type I, 3,8,13,18-tetrachloro-2,7,12,17-tetramethoxyporphyrin in approximately 6% yield. © 2011 Elsevier Ltd. All rights reserved.
Description
Keywords
β-Tetrachlorotetramethoxyporphyrin,
3,4-Dimethoxypyrrole,
3-Chloro-4-methoxypyrrole-2- aldehyde,
Asymmetric pyrrole,
Vilsmeier-Haack formylation of pyrrole
Citation
Tetrahedron Letters. v.52(21)