Efficient Synthesis of Functionalized β-Keto Esters and β-Diketones through Regioselective Hydration of Alkynyl Esters and Alkynyl Ketones by Use of a Cationic NHC–Au < sup > I < /sup > Catalyst
Efficient Synthesis of Functionalized β-Keto Esters and β-Diketones through Regioselective Hydration of Alkynyl Esters and Alkynyl Ketones by Use of a Cationic NHC–Au < sup > I < /sup > Catalyst
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Date
2016-12-01
Authors
Tarigopula, Chandrahas
Thota, Ganesh Kumar
Balamurugan, Rengarajan
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Journal ISSN
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Abstract
Regioselective hydration of α-alkynyl esters and ketones by using a cationic NHC–AuIcatalyst results in β-keto esters and β-diketones, respectively. Controlled release of water in acetone by aldol self-condensation under the reaction conditions makes acetone as better solvent than 1,4-dioxane/water for the hydration of α-alkynyl esters having sensitive ester moieties.
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Keywords
Alkynes,
Gold,
Homogeneous catalysis,
Hydration,
β-Diketones,
β-Keto esters
Citation
European Journal of Organic Chemistry. v.2016(35)