New methods of resolution of racemic diols using (S)-proline
New methods of resolution of racemic diols using (S)-proline
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Date
1998-10-14
Authors
Periasamy, Mariappan
Ramanathan, C. Ramaraj
Prasad, A. S.Bhanu
Kanth, J. V.Bhaskar
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Racemic 1,2-diphenyl-1,2-ethanediol is resolved to obtain (S,S)-isomer in 99% ee through complexation with boric acid and (S)-proline. The racemic 1,1,2-triphenyl-1,2-ethanediol has been resolved to give (S)-isomer in 94% ee using (S)-proline alone by refluxing in benzene.
Description
Keywords
(S)-proline,
1,1,2-triphenyl-1,2-ethanediol,
1,2-diphenyl-1,2-ethanediol,
Borate complex,
Boric acid,
Resolution
Citation
Enantiomer. v.3(1)