Expeditious synthetic route to B-ring functionalised 2-oxa-steroids: Synthesis of 17-ethylenedioxy-6α-hydroxy-2-oxa-4-androsten-3-one as key synthon
Expeditious synthetic route to B-ring functionalised 2-oxa-steroids: Synthesis of 17-ethylenedioxy-6α-hydroxy-2-oxa-4-androsten-3-one as key synthon
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Date
1997-12-01
Authors
Nangia, Ashwini
Anthony, A.
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Abstract
The easily prepared 17-ethylenedioxy-4-androsten-3,6-dione 8 is transformed to 17-ethylenedioxy-6α-hydroxy-2-oxa-4-androsten-3-one 15 in a few steps with complete stereo- and regio-control. The hydroxylactone 15 provides an easy entry to B-ring functionalised 2-oxa-androgens for evaluation as potential aromatase inhibitors and anabolic agents.
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Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. v.36(12)