Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity
Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity
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Date
1989-01-01
Authors
Ramesh Reddy, G.
Veera Babu, G. R.
Reddanna, P.
Chetty, C. S.
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Abstract
Substrate kinetics of succinate dehydrogenase (EC 1.3.99.1) were studied in the brain of control and dieldrin-treated albino rats. Dieldrin inhibited the enzyme activity to various degrees and also altered the Michaelis-Menten constant (Km) of the enzyme. Activation energy values (ΔE) were increased, suggesting decreaed maximal velocity Vmax, and the high Km obtained for the enzyme also revealed decreased enzyme-substrate affinity and masking of active sites by dieldrin. © 1989.
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Ecotoxicology and Environmental Safety. v.18(2)