PEG-SO <inf>3</inf>H catalyzed synthesis and cytotoxicity of α-aminophosphonates
PEG-SO <inf>3</inf>H catalyzed synthesis and cytotoxicity of α-aminophosphonates
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Date
2012-01-01
Authors
Reddy, C. Bhupendra
Kumar, K. Suresh
Kumar, M. Anil
Narayana Reddy, M. Veera
Krishna, B. Satheesh
Naveen, M.
Arunasree, M. K.
Reddy, C. Suresh
Raju, C. Naga
Reddy, C. Devendranath
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Abstract
One pot three-component PEG-SO 3H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik-Field's reaction. These new structurally diversified set of α-aminophosphonates (4a-j) were evaluated for their anti-tumor activity on human chronic myeloid leukemia cells (K 562), human colon carcinoma cells (Colo 205) along with non-cancerous human embryonic kidney cells (HEK 293). They showed moderate activity on both cancerous cells and non-cancerous cells. © 2011 Elsevier Masson SAS. All rights reserved.
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Keywords
4-(Pyridin-4-yl)benzaldehyde,
Human chronic myeloid leukemia cells (K 562),
Human colon carcinoma cells (Colo 205),
Human embryonic kidney cells (HEK 293),
Poly ethylene glycol sulfonic acid (PEG-SO H) 3
Citation
European Journal of Medicinal Chemistry. v.47(1)