The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
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Date
2018-12-06
Authors
Kiran, Shashi
Dar, Ashraf
Singh, Samarendra K.
Lee, Kyung Yong
Dutta, Anindya
Journal Title
Journal ISSN
Volume Title
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Abstract
The oncogenes E6 and E7 from high-risk HPVs induce many cancers. Kiran et al. show that the E6 protein from oncogenic HPV associates with USP46 and directs USP46 to deubiquitinate and stabilize cellular proteins like Cdt2 to promote cell proliferation and tumor growth, making USP46 an attractive target for therapy.
Description
Keywords
Cdt2,
cervical cancer,
deubiquitinase,
E6,
HPV,
oncogenic virus,
USP46
Citation
Molecular Cell. v.72(5)